Abstract: During 2012 - 2 014， the research on the artificial breeding technique of Babylonia lutosa was conducted by collecting a number of 5 775 wild broodstock of Babylonia lutosa. After breeding，5 246 of Babylonia lutosa were survived， and the survival rate was 90.8% . The breeding season of broodstock was from June to September， and the peak period appeared when the water temperature was between 26℃ ?30℃ . Oocyst was trapezoid or saddle shaped and transparent. There were 309 ?472 eggs in one Oocyst， 381 by average. Adding Isochrysis zhanjiangensis， Chaetoceros muelleri and algae with high concentration of H U F A into diary as supplementary could improve the survival rate. More， the metamorphosis rate raised progressively in 3 years’test. Finally， 17.3 385 million of juveniles with the shell height of 3.08 mm to 15.91 mm were successfully bred. Meanwhile， the metamorphosis of the whole early developmental stages of Babylonia lutosa，which was divided into 16 stages， was observed under microscope.